6WDU
The external aldimine form of the Salmonella thypi wild-type tryptophan synthase in open conformation showing multiple side chain conformations for the residue beta Q114 and sodium ion at the metal coordination site. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring.
Summary for 6WDU
Entry DOI | 10.2210/pdb6wdu/pdb |
Related | 6dz4 6dzo |
Descriptor | Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 1,2-ETHANEDIOL, ... (8 entities in total) |
Functional Keywords | lyase-inhibitor, protein complex, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) More |
Total number of polymer chains | 2 |
Total formula weight | 73800.52 |
Authors | Hilario, E.,Fan, L.,Dunn, M.F.,Mueller, L.J. (deposition date: 2020-04-01, release date: 2021-03-10, Last modification date: 2023-10-18) |
Primary citation | Hilario, E.,Fan, L.,Dunn, M.F.,Mueller, L.J. The external aldimine form of the Salmonella thypi wild-type tryptophan synthase in open conformation showing multiple side chain conformations for the residue beta Q114 and sodium ion at the metal coordination site. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring. To be Published, |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report