6W8W
Crystal structure of mouse DNMT1 in complex with CCG DNA
Summary for 6W8W
Entry DOI | 10.2210/pdb6w8w/pdb |
Descriptor | DNA (cytosine-5)-methyltransferase 1, CCG DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3'), CCG DNA (5'-D(*CP*CP*TP*TP*CP*(C49)P*GP*TP*AP*AP*GP*T)-3'), ... (6 entities in total) |
Functional Keywords | dnmt1, protein-dna complex, dna methylation, epigenetics, transferase, transferase-dna complex, transferase/dna |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 213797.40 |
Authors | Anteneh, H.,Song, J. (deposition date: 2020-03-21, release date: 2020-07-08, Last modification date: 2023-10-18) |
Primary citation | Adam, S.,Anteneh, H.,Hornisch, M.,Wagner, V.,Lu, J.,Radde, N.E.,Bashtrykov, P.,Song, J.,Jeltsch, A. DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context Nat Commun, 2020 |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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