6W6W
Cryo-EM structure of CST bound to telomeric single-stranded DNA
Summary for 6W6W
Entry DOI | 10.2210/pdb6w6w/pdb |
EMDB information | 21567 |
Descriptor | CST complex subunit CTC1, DNA (5'-D(P*TP*AP*GP*G)-3'), CST complex subunit STN1, ... (5 entities in total) |
Functional Keywords | telomere homeostasis, telomere packaging, telomerase terminator, dna replication, double-stranded breaks repair, single-stranded dna-binding proteins, higher-order protein assembly, dna-induced oligomeriization, structural protein, structural protein-dna complex, structural protein/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 335075.66 |
Authors | Lim, C.,Barbour, A.T.,Zaug, A.J.,Goodrich, K.J.,McKay, A.E.,Wuttke, D.S.,Cech, T.R. (deposition date: 2020-03-17, release date: 2020-06-03, Last modification date: 2020-06-17) |
Primary citation | Lim, C.J.,Barbour, A.T.,Zaug, A.J.,Goodrich, K.J.,McKay, A.E.,Wuttke, D.S.,Cech, T.R. The structure of human CST reveals a decameric assembly bound to telomeric DNA. Science, 368:1081-1085, 2020 Cited by PubMed: 32499435DOI: 10.1126/science.aaz9649 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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