6W6W

Cryo-EM structure of CST bound to telomeric single-stranded DNA

6W6W の概要

• エントリーDOI: 10.2210/pdb6w6w/pdb
• EMDBエントリー: 21567
• 分子名称: CST complex subunit CTC1, DNA (5'-D(P*TP*AP*GP*G)-3'), CST complex subunit STN1, ... (5 entities in total)
• 機能のキーワード: telomere homeostasis, telomere packaging, telomerase terminator, dna replication, double-stranded breaks repair, single-stranded dna-binding proteins, higher-order protein assembly, dna-induced oligomeriization, structural protein, structural protein-dna complex, structural protein/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 335075.66

構造登録者

Lim, C.,Barbour, A.T.,Zaug, A.J.,Goodrich, K.J.,McKay, A.E.,Wuttke, D.S.,Cech, T.R. (登録日: 2020-03-17, 公開日: 2020-06-03, 最終更新日: 2020-06-17)

• 主引用文献: Lim, C.J.,Barbour, A.T.,Zaug, A.J.,Goodrich, K.J.,McKay, A.E.,Wuttke, D.S.,Cech, T.R.; The structure of human CST reveals a decameric assembly bound to telomeric DNA.; Science, 368:1081-1085, 2020; PubMed: 32499435; DOI: 10.1126/science.aaz9649

実験手法

ELECTRON MICROSCOPY (3 Å)