6W65

Human PARP16 in complex with RBN010860

Summary for 6W65

Entry DOI	10.2210/pdb6w65/pdb
Related	4F0D 6HXR 6HXS
Descriptor	Protein mono-ADP-ribosyltransferase PARP16, 5-{5-[(piperidin-4-yl)oxy]-2H-isoindol-2-yl}-4-(trifluoromethyl)pyridazin-3(2H)-one, CITRIC ACID, ... (7 entities in total)
Functional Keywords	adp-ribose, parp16, artd15, artd transferase domain, adp-ribosylation, transferase-transferase inhibitor complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	96232.48
Authors	Swinger, K.K.,Wigle, T.J.,Kuntz, K.W. (deposition date: 2020-03-16, release date: 2020-10-07, Last modification date: 2024-03-06)
Primary citation	Wigle, T.J.,Blackwell, D.J.,Schenkel, L.B.,Ren, Y.,Church, W.D.,Desai, H.J.,Swinger, K.K.,Santospago, A.G.,Majer, C.R.,Lu, A.Z.,Niepel, M.,Perl, N.R.,Vasbinder, M.M.,Keilhack, H.,Kuntz, K.W. In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement. Cell Chem Biol, 27:877-887.e14, 2020 Cited by PubMed: 32679093 DOI: 10.1016/j.chembiol.2020.06.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation