6W5V
NPC1-NPC2 complex structure at pH 5.5
Summary for 6W5V
Entry DOI | 10.2210/pdb6w5v/pdb |
EMDB information | 21545 21546 21547 21548 21549 |
Descriptor | NPC intracellular cholesterol transporter 1, NPC intracellular cholesterol transporter 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | cholesterol lysosome, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 169672.48 |
Authors | Yan, N.,Qian, H.W.,Wu, X.L. (deposition date: 2020-03-13, release date: 2020-06-17, Last modification date: 2020-07-29) |
Primary citation | Qian, H.,Wu, X.,Du, X.,Yao, X.,Zhao, X.,Lee, J.,Yang, H.,Yan, N. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell, 182:98-111.e18, 2020 Cited by PubMed: 32544384DOI: 10.1016/j.cell.2020.05.020 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4 Å) |
Structure validation
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