6W51
Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H
Summary for 6W51
Entry DOI | 10.2210/pdb6w51/pdb |
Descriptor | MHC class I antigen, Beta-2-microglobulin, Cellular tumor antigen p53 peptide, ... (7 entities in total) |
Functional Keywords | immunotherapy, mhc-i, hla-a2, p53, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 20 |
Total formula weight | 386132.70 |
Authors | Wright, K.M.,Gabelli, S.B. (deposition date: 2020-03-12, release date: 2021-03-17, Last modification date: 2023-10-18) |
Primary citation | Hsiue, E.H.,Wright, K.M.,Douglass, J.,Hwang, M.S.,Mog, B.J.,Pearlman, A.H.,Paul, S.,DiNapoli, S.R.,Konig, M.F.,Wang, Q.,Schaefer, A.,Miller, M.S.,Skora, A.D.,Azurmendi, P.A.,Murphy, M.B.,Liu, Q.,Watson, E.,Li, Y.,Pardoll, D.M.,Bettegowda, C.,Papadopoulos, N.,Kinzler, K.W.,Vogelstein, B.,Gabelli, S.B.,Zhou, S. Targeting a neoantigen derived from a common TP53 mutation. Science, 371:-, 2021 Cited by PubMed: 33649166DOI: 10.1126/science.abc8697 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.53 Å) |
Structure validation
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