6W4M

CRYSTAL STRUCTURE OF THE ADCC-POTENT, WEAKLY NEUTRALIZING HIV ENV CO-RECEPTOR BINDING SITE ANTIBODY N12-I2 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND M48U1

「5UWE」から置き換えられました

6W4M の概要

• エントリーDOI: 10.2210/pdb6w4m/pdb
• 分子名称: clade A/E 93TH057 HIV-1 gp120 core, ANTI-HIV ANTIBODY N12-I2 FAB LIGHT CHAIN, ANTI-HIV ANTIBODY N12-I2 FAB HEAVY CHAIN, ... (5 entities in total)
• 機能のキーワード: adcc and neutralizing anti-hiv-1 env antibody n12-i2, cd4i antibody, fab fragment, hiv-1 gp120, immune system, clade a/e 93th057, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 93456.73

構造登録者

Tolbert, W.D.,Gohain, N.,Pazgier, M. (登録日: 2020-03-11, 公開日: 2020-08-05, 最終更新日: 2023-11-15)

• 主引用文献: Tolbert, W.D.,Sherburn, R.,Gohain, N.,Ding, S.,Flinko, R.,Orlandi, C.,Ray, K.,Finzi, A.,Lewis, G.K.,Pazgier, M.; Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site.; Bmc Biol., 18:91-91, 2020; PubMed: 32693837; DOI: 10.1186/s12915-020-00819-y

実験手法

X-RAY DIFFRACTION (3.2 Å)