6W4M

CRYSTAL STRUCTURE OF THE ADCC-POTENT, WEAKLY NEUTRALIZING HIV ENV CO-RECEPTOR BINDING SITE ANTIBODY N12-I2 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND M48U1

「5UWE」から置き換えられました

6W4M の概要

• エントリーDOI: 10.2210/pdb6w4m/pdb
• 分子名称: clade A/E 93TH057 HIV-1 gp120 core, ANTI-HIV ANTIBODY N12-I2 FAB LIGHT CHAIN, ANTI-HIV ANTIBODY N12-I2 FAB HEAVY CHAIN, ... (5 entities in total)
• 機能のキーワード: adcc and neutralizing anti-hiv-1 env antibody n12-i2, cd4i antibody, fab fragment, hiv-1 gp120, immune system, clade a/e 93th057, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 93456.73

構造登録者

Tolbert, W.D.,Gohain, N.,Pazgier, M. (登録日: 2020-03-11, 公開日: 2020-08-05, 最終更新日: 2023-11-15)

主引用文献

Tolbert, W.D.,Sherburn, R.,Gohain, N.,Ding, S.,Flinko, R.,Orlandi, C.,Ray, K.,Finzi, A.,Lewis, G.K.,Pazgier, M.
Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site.
Bmc Biol., 18:91-91, 2020

PubMed Abstract: The binding of HIV-1 Envelope glycoproteins (Env) to host receptor CD4 exposes vulnerable conserved epitopes within the co-receptor binding site (CoRBS) which are required for the engagement of either CCR5 or CXCR4 co-receptor to allow HIV-1 entry. Antibodies against this region have been implicated in the protection against HIV acquisition in non-human primate (NHP) challenge studies and found to act synergistically with antibodies of other specificities to deliver effective Fc-mediated effector function against HIV-1-infected cells. Here, we describe the structure and function of N12-i2, an antibody isolated from an HIV-1-infected individual, and show how the unique structural features of this antibody allow for its effective Env recognition and Fc-mediated effector function.

PubMed: 32693837
DOI: 10.1186/s12915-020-00819-y

実験手法

X-RAY DIFFRACTION (3.2 Å)