6W4I
APE1 Y269A product complex with abasic DNA
Summary for 6W4I
Entry DOI | 10.2210/pdb6w4i/pdb |
Descriptor | DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(P*(3DR)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (6 entities in total) |
Functional Keywords | dna repair, ap-endonuclease, dna binding, dna binding protein, lyase-dna complex, lyase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 87711.14 |
Authors | Freudenthal, B.D.,Hoitsma, N.M. (deposition date: 2020-03-10, release date: 2020-06-17, Last modification date: 2023-10-18) |
Primary citation | Hoitsma, N.M.,Whitaker, A.M.,Beckwitt, E.C.,Jang, S.,Agarwal, P.K.,Van Houten, B.,Freudenthal, B.D. AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop. Nucleic Acids Res., 48:7345-7355, 2020 Cited by PubMed: 32542366DOI: 10.1093/nar/gkaa496 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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