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6W4I

APE1 Y269A product complex with abasic DNA

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BDNA-(apurinic or apyrimidinic site) lyasepolymer27631064.42UniProt (P27695)
Pfam (PF03372)
In PDB
Homo sapiens (Human)APEX nuclease,APEN,Apurinic-apyrimidinic endonuclease 1,APE-1,REF-1,Redox factor-1
2D, CDNA (5'-D(P*(3DR)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3')polymer113210.12synthetic construct
3P, EDNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3')polymer103061.02synthetic construct
4V, FDNA (5'-D(P*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3')polymer216465.22synthetic construct
5A, BMANGANESE (II) IONnon-polymer54.92Chemie (MN)
6waterwater18.0363Chemie (HOH)
Sequence modifications
A, B: 43 - 318 (UniProt: P27695)
PDBExternal DatabaseDetails
Ala 138Cys 138engineered mutation
Ala 269Tyr 269engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight87601.3
Non-Polymers*Number of molecules2
Total formula weight109.9
All*Total formula weight87711.1
*Water molecules are not included.

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PDB entries from 2024-06-12

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