6VZH

Structure of Human Vaccinia-related Kinase 1 (VRK1) Bound to LDSM311

Summary for 6VZH

• Entry DOI: 10.2210/pdb6vzh/pdb
• Descriptor: Serine/threonine-protein kinase VRK1, SULFATE ION, (7~{R})-2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7-dimethyl-8-prop-2-ynyl-7~{H}-pteridin-6-one, ... (5 entities in total)
• Functional Keywords: protein kinase, inhibitor, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 166197.80

Authors

dos Reis, C.V.,Dutra, L.A.,Gama, F.,Ferreira, M.,Mascarello, A.,Azevedo, H.,Guimaraes, C.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Counago, R.M.,Structural Genomics Consortium (SGC) (deposition date: 2020-02-28, release date: 2020-03-11, Last modification date: 2023-10-11)

• Primary citation: dos Reis, C.V.,Dutra, L.A.,Gama, F.,Ferreira, M.,Mascarello, A.,Azevedo, H.,Guimaraes, C.R.W.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Counago, R.M.; Structure of Human Vaccinia-related Kinase 1 (VRK1) Bound to LDSM311; To be Published,

Experimental method

X-RAY DIFFRACTION (2.55 Å)