6VZH
Structure of Human Vaccinia-related Kinase 1 (VRK1) Bound to LDSM311
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Serine/threonine-protein kinase VRK1 | polymer | 364 | 41138.1 | 4 | UniProt (Q99986) Pfam (PF00069) | Homo sapiens (Human) | Vaccinia-related kinase 1 |
| 2 | E, F, G, H, I... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 3 | J, P (B, D) | (7~{R})-2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7-dimethyl-8-prop-2-ynyl-7~{H}-pteridin-6-one | non-polymer | 359.3 | 2 | Chemie (RYA) | |||
| 4 | O (D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 364 (UniProt: Q99986)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| Met 2 | - | expression tag |
| Ala 34 | Lys 34 | engineered mutation |
| Ala 35 | Lys 35 | engineered mutation |
| Ala 36 | Glu 36 | engineered mutation |
| Ala 212 | Glu 212 | engineered mutation |
| Ala 214 | Lys 214 | engineered mutation |
| Ala 215 | Glu 215 | engineered mutation |
| Ala 292 | Glu 292 | engineered mutation |
| Ala 293 | Lys 293 | engineered mutation |
| Ala 295 | Lys 295 | engineered mutation |
| Ala 359 | Lys 359 | engineered mutation |
| Ala 360 | Lys 360 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 164552.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1645.3 | |
| All* | Total formula weight | 166197.8 |
