6VVU
Anti-Tryptase fab E104.v1 bound to tryptase
Summary for 6VVU
Entry DOI | 10.2210/pdb6vvu/pdb |
Descriptor | Tryptase alpha/beta-1, Fab E104.v1 heavy chain, Fab E104.v1 light chain, ... (6 entities in total) |
Functional Keywords | fab, inhibitor, tryptase, immune system, hydrolase-immune system complex, hydrolase/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 315233.71 |
Authors | Ultsch, M.,Koerber, J.T. (deposition date: 2020-02-18, release date: 2020-12-30, Last modification date: 2023-10-11) |
Primary citation | Maun, H.R.,Vij, R.,Walters, B.T.,Morando, A.,Jackman, J.K.,Wu, P.,Estevez, A.,Chen, X.,Franke, Y.,Lipari, M.T.,Dennis, M.S.,Kirchhofer, D.,Ciferri, C.,Loyet, K.M.,Yi, T.,Eigenbrot, C.,Lazarus, R.A.,Koerber, J.T. Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge. Nat Commun, 11:6435-6435, 2020 Cited by PubMed: 33353951DOI: 10.1038/s41467-020-20143-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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