6VSW

Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORgt

Summary for 6VSW

Entry DOI	10.2210/pdb6vsw/pdb
Descriptor	RAR-related orphan receptor C, 5-(2,3-dichloro-4-{[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl}phenyl)-4-(4-fluoropiperidine-1-carbonyl)-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide (2 entities in total)
Functional Keywords	nuclear receptor rorgt, nuclear protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	55451.63
Authors	Spurlino, J.,Milligan, C. (deposition date: 2020-02-12, release date: 2020-05-13, Last modification date: 2023-10-11)
Primary citation	Gege, C.,Albers, M.,Kinzel, O.,Kleymann, G.,Schluter, T.,Steeneck, C.,Hoffmann, T.,Xue, X.,Cummings, M.D.,Spurlino, J.,Milligan, C.,Fourie, A.M.,Edwards, J.P.,Leonard, K.,Coe, K.,Scott, B.,Pippel, D.,Goldberg, S.D. Optimization and biological evaluation of thiazole-bis-amide inverse agonists of ROR gamma t. Bioorg.Med.Chem.Lett., 30:127205-127205, 2020 Cited by PubMed: 32336498 DOI: 10.1016/j.bmcl.2020.127205 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.202 Å)

Structure validation