6VSW

Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORgt

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	RAR-related orphan receptor C	polymer	232	27076.3	2	UniProt (Q6I9R9) Pfam (PF00104) UniProt (by SIFTS) (P51449) In PDB	Homo sapiens (Human)	RORC protein
2	A, B	5-(2,3-dichloro-4-{[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl}phenyl)-4-(4-fluoropiperidine-1-carbonyl)-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide	non-polymer		649.5	2	Chemie (RG7)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	54152.6
Non-Polymers*	Number of molecules	2
	Total formula weight	1299.0
All*	Total formula weight	55451.6

*Water molecules are not included.