6VR3

Aminoglycoside N-2'-Acetyltransferase-Ia [AAC(2')-Ia] in complex with acetylated-netilmicin and CoA

Summary for 6VR3

• Entry DOI: 10.2210/pdb6vr3/pdb
• Related: 6VOU 6VR2
• Descriptor: Aminoglycoside 2'-N-acetyltransferase, N-[(2S,3R)-2-{[(1R,2S,3S,4R,6S)-6-amino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-lyxopyranosyl]oxy}-4-(ethylamino) -2-hydroxycyclohexyl]oxy}-6-(aminomethyl)-3,4-dihydro-2H-pyran-3-yl]acetamide, COENZYME A, ... (4 entities in total)
• Functional Keywords: acetyltransferase, gnat superfamily, transferase
• Biological source: Providencia stuartii
• Total number of polymer chains: 2
• Total formula weight: 43063.98

Authors

Bassenden, A.V.,Berghuis, A.M. (deposition date: 2020-02-06, release date: 2021-06-02, Last modification date: 2023-10-11)

• Primary citation: Bassenden, A.V.,Dumalo, L.,Park, J.,Blanchet, J.,Maiti, K.,Arya, D.P.,Berghuis, A.M.; Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2') enzymes.; Sci Rep, 11:11614-11614, 2021; PubMed: 34078922; DOI: 10.1038/s41598-021-89446-3

Experimental method

X-RAY DIFFRACTION (2 Å)