6VR2

Aminoglycoside N-2'-Acetyltransferase-Ia [AAC(2')-Ia] in complex with acetylated-tobramycin and CoA

Summary for 6VR2

Entry DOI	10.2210/pdb6vr2/pdb
Related	6VOU
Descriptor	Aminoglycoside 2'-N-acetyltransferase, (1S,2S,3R,4S,6R)-3-{[2-(acetylamino)-6-amino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl]oxy}-4,6-diamino-2-hydroxycycloh exyl 3-amino-3-deoxy-alpha-D-glucopyranoside, COENZYME A, ... (5 entities in total)
Functional Keywords	acetyltransferase, gnat superfamily, transferase
Biological source	Providencia stuartii
Total number of polymer chains	2
Total formula weight	43184.86
Authors	Bassenden, A.V.,Berghuis, A.M. (deposition date: 2020-02-06, release date: 2021-06-02, Last modification date: 2023-10-11)
Primary citation	Bassenden, A.V.,Dumalo, L.,Park, J.,Blanchet, J.,Maiti, K.,Arya, D.P.,Berghuis, A.M. Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2') enzymes. Sci Rep, 11:11614-11614, 2021 Cited by PubMed: 34078922 DOI: 10.1038/s41598-021-89446-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation