6VPI
TPX2 residues 7-20 fused to Aurora A residues 116-389 C247V + D256N + C319V triple mutant disulfide homodimer in complex with AMP-PNP
Summary for 6VPI
Entry DOI | 10.2210/pdb6vpi/pdb |
Descriptor | TPX2 fragment - Aurora A kinase domain fusion, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | ser/thr kinase, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 34556.61 |
Authors | Lim, D.C.,Yaffe, M.B. (deposition date: 2020-02-03, release date: 2020-08-05, Last modification date: 2023-10-11) |
Primary citation | Lim, D.C.,Joukov, V.,Rettenmaier, T.J.,Kumagai, A.,Dunphy, W.G.,Wells, J.A.,Yaffe, M.B. Redox priming promotes Aurora A activation during mitosis. Sci.Signal., 13:-, 2020 Cited by PubMed: 32694171DOI: 10.1126/scisignal.abb6707 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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