6VPI
TPX2 residues 7-20 fused to Aurora A residues 116-389 C247V + D256N + C319V triple mutant disulfide homodimer in complex with AMP-PNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TPX2 fragment - Aurora A kinase domain fusion | polymer | 292 | 33897.7 | 1 | UniProt (Q9ULW0) UniProt (O14965) Pfam (PF00069) | Homo sapiens (Human) | Targeting protein for Xklp2,Aurora kinase A,Differentially expressed in cancerous and non-cancerous lung cells 2,DIL-2,Hepatocellular carcinoma-associated antigen 519,Hepatocellular carcinoma-associated antigen 90,Protein fls353,Restricted expression proliferation-associated protein 100,p100,Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | B (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (A) | MALONIC ACID | non-polymer | 104.1 | 1 | Chemie (MLA) | |||
| 5 | F (A) | water | water | 18.0 | 233 | Chemie (HOH) |
Sequence modifications
A: 7 - 20 (UniProt: Q9ULW0)
A: 116 - 389 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Ala 4 | - | expression tag |
| His 5 | - | expression tag |
| Met 6 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Val 247 | Cys 247 | conflict |
| Asn 256 | Asp 256 | conflict |
| Val 319 | Cys 319 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33897.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 658.9 | |
| All* | Total formula weight | 34556.6 |
