6VO7

Crystal structure of PI3K-alpha Ras Binding Domain (RBD)

Summary for 6VO7

Entry DOI	10.2210/pdb6vo7/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (2 entities in total)
Functional Keywords	ras binding domain, oncogenic signaling, effector, oncoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16799.79
Authors	Carey, L.M.,Martinez, N.G.,Campbell, S. (deposition date: 2020-01-30, release date: 2021-02-03, Last modification date: 2023-10-11)
Primary citation	Martinez, N.G.,Thieker, D.F.,Carey, L.M.,Rasquinha, J.A.,Kistler, S.K.,Kuhlman, B.A.,Campbell, S.L. Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3K alpha and PI3K gamma. J.Mol.Biol., 433:166838-166838, 2021 Cited by PubMed: 33539876 DOI: 10.1016/j.jmb.2021.166838 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.31 Å)

Structure validation