6VNF
JAK2 JH1 in complex with MA9-086
Summary for 6VNF
Entry DOI | 10.2210/pdb6vnf/pdb |
Descriptor | Tyrosine-protein kinase JAK2, N~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1H-indol-6-yl]-N~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine (3 entities in total) |
Functional Keywords | janus associated kinase, jak2, kinase domain, jh1, kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 74016.29 |
Authors | Davis, R.R.,Schonbrunn, E. (deposition date: 2020-01-29, release date: 2021-02-17, Last modification date: 2023-11-15) |
Primary citation | Davis, R.R.,Li, B.,Yun, S.Y.,Chan, A.,Nareddy, P.,Gunawan, S.,Ayaz, M.,Lawrence, H.R.,Reuther, G.W.,Lawrence, N.J.,Schonbrunn, E. Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof. J.Med.Chem., 64:2228-2241, 2021 Cited by PubMed: 33570945DOI: 10.1021/acs.jmedchem.0c01952 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)