6VNF

JAK2 JH1 in complex with MA9-086

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Tyrosine-protein kinase JAK2	polymer	308	36455.4	2	UniProt (O60674) Pfam (PF07714)	Homo sapiens (Human)	Janus kinase 2,JAK-2
2	C, D (B, A)	N~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1H-indol-6-yl]-N~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	non-polymer		552.7	2	Chemie (R6S)
3	E, F (B, A)	water	water		18.0	152	Chemie (HOH)

Sequence modifications

B, A: 840 - 1132 (UniProt: O60674)

PDB	External Database	Details
His 825	-	expression tag
His 826	-	expression tag
His 827	-	expression tag
His 828	-	expression tag
His 829	-	expression tag
His 830	-	expression tag
His 831	-	expression tag
His 832	-	expression tag
Glu 833	-	expression tag
Asn 834	-	expression tag
Leu 835	-	expression tag
Tyr 836	-	expression tag
Phe 837	-	expression tag
Gln 838	-	expression tag
Gly 839	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72910.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1105.4
All*	Total formula weight	74016.3

*Water molecules are not included.