6VLT

Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan

Summary for 6VLT

• Entry DOI: 10.2210/pdb6vlt/pdb
• Descriptor: Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol, ... (6 entities in total)
• Functional Keywords: cyp2c9*2, cyp2c9 r144c, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 446014.05

Authors

Shah, M.B. (deposition date: 2020-01-25, release date: 2020-09-30, Last modification date: 2024-04-03)

• Primary citation: Parikh, S.J.,Evans, C.M.,Obi, J.O.,Zhang, Q.,Maekawa, K.,Glass, K.C.,Shah, M.B.; Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism.; Mol.Pharmacol., 98:529-539, 2020; PubMed: 32938720; DOI: 10.1124/molpharm.120.000042

Experimental method

X-RAY DIFFRACTION (3.12 Å)