6VHY
NpsA-ThdA, an artificially fused Adenylation-PCP di-domain NRPS from Klebsiella oxytoca
Summary for 6VHY
Entry DOI | 10.2210/pdb6vhy/pdb |
Descriptor | NpsA Adenylation Domain, Non-ribosomal peptide synthetase fusion protein, 5'-deoxy-5'-({[(2R)-2-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}-2-(3-hydroxyphenyl)ethyl]sulfonyl}amino)adenosine (3 entities in total) |
Functional Keywords | adenylation, tilivalline, tilimycin, nrps, nonribosomal peptide synthetase, biosynthetic protein |
Biological source | Klebsiella oxytoca More |
Total number of polymer chains | 4 |
Total formula weight | 259477.30 |
Authors | Kreitler, D.F.,Gulick, A.M. (deposition date: 2020-01-10, release date: 2020-06-24, Last modification date: 2023-10-11) |
Primary citation | Alexander, E.M.,Kreitler, D.F.,Guidolin, V.,Hurben, A.K.,Drake, E.,Villalta, P.W.,Balbo, S.,Gulick, A.M.,Aldrich, C.C. Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic PathogenKlebsiella oxytoca. Acs Infect Dis., 6:1976-1997, 2020 Cited by PubMed: 32485104DOI: 10.1021/acsinfecdis.0c00326 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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