6VHY

NpsA-ThdA, an artificially fused Adenylation-PCP di-domain NRPS from Klebsiella oxytoca

Summary for 6VHY

Entry DOI	10.2210/pdb6vhy/pdb
Descriptor	NpsA Adenylation Domain, Non-ribosomal peptide synthetase fusion protein, 5'-deoxy-5'-({[(2R)-2-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}-2-(3-hydroxyphenyl)ethyl]sulfonyl}amino)adenosine (3 entities in total)
Functional Keywords	adenylation, tilivalline, tilimycin, nrps, nonribosomal peptide synthetase, biosynthetic protein
Biological source	Klebsiella oxytoca More
Total number of polymer chains	4
Total formula weight	259477.30
Authors	Kreitler, D.F.,Gulick, A.M. (deposition date: 2020-01-10, release date: 2020-06-24, Last modification date: 2023-10-11)
Primary citation	Alexander, E.M.,Kreitler, D.F.,Guidolin, V.,Hurben, A.K.,Drake, E.,Villalta, P.W.,Balbo, S.,Gulick, A.M.,Aldrich, C.C. Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic PathogenKlebsiella oxytoca. Acs Infect Dis., 6:1976-1997, 2020 Cited by PubMed: 32485104 DOI: 10.1021/acsinfecdis.0c00326 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation