6VGH

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant In Complex with Lasofoxifene

Summary for 6VGH

• Entry DOI: 10.2210/pdb6vgh/pdb
• Descriptor: Estrogen receptor, (5R,6S)-6-PHENYL-5-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]-5,6,7,8-TETRAHYDRONAPHTHALEN-2-OL (3 entities in total)
• Functional Keywords: breast cancer, steroid receptor, activating mutant, selective estrogen receptor modulator, antiestrogen, lasofoxifene, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 60895.16

Authors

Fanning, S.W.,Greene, G.L. (deposition date: 2020-01-08, release date: 2020-02-12, Last modification date: 2023-10-11)

• Primary citation: Fanning, S.W.; Ligand Binding Domain; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)