6VGH
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant In Complex with Lasofoxifene
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue C3D A 601 |
| Chain | Residue |
| A | MET343 |
| A | MET421 |
| A | LEU525 |
| A | HOH737 |
| A | LEU346 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | TRP383 |
| A | LEU387 |
| A | LEU391 |
| A | ARG394 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue C3D B 601 |
| Chain | Residue |
| B | MET343 |
| B | LEU346 |
| B | THR347 |
| B | ALA350 |
| B | ASP351 |
| B | GLU353 |
| B | TRP383 |
| B | LEU387 |
| B | LEU391 |
| B | ARG394 |
| B | LEU525 |
| B | HOH764 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
