6VGD

Crystal structure of the DNA binding domain (DBD) of human FLI1 and the complex of the DBD of human Runx2 with core binding factor beta (Cbfb), in complex with 16mer DNA CAGAGGATGTGGCTTC

6VGD の概要

• エントリーDOI: 10.2210/pdb6vgd/pdb
• 分子名称: Friend leukemia integration 1 transcription factor, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... (5 entities in total)
• 機能のキーワード: ewing sarcoma, enhancer, transcription factor, oncogenesis, prostate cancer, ets-family, runt-family, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 59701.55

構造登録者

Hou, C.,Tsodikov, O.V. (登録日: 2020-01-07, 公開日: 2020-11-25, 最終更新日: 2023-10-11)

• 主引用文献: Hou, C.,Mandal, A.,Rohr, J.,Tsodikov, O.V.; Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.; Structure, 29:404-412.e4, 2021; PubMed: 33275876; DOI: 10.1016/j.str.2020.11.012

実験手法

X-RAY DIFFRACTION (4.2 Å)