6VGD
Crystal structure of the DNA binding domain (DBD) of human FLI1 and the complex of the DBD of human Runx2 with core binding factor beta (Cbfb), in complex with 16mer DNA CAGAGGATGTGGCTTC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Friend leukemia integration 1 transcription factor | polymer | 104 | 12098.7 | 1 | UniProt (Q01543) Pfam (PF00178) | Homo sapiens (Human) | Proto-oncogene Fli-1,Transcription factor ERGB |
| 2 | B (B) | DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') | polymer | 16 | 4954.2 | 1 | Homo sapiens | ||
| 3 | C (C) | DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3') | polymer | 16 | 4843.2 | 1 | Homo sapiens | ||
| 4 | D (D) | Runt-related transcription factor 2 | polymer | 177 | 19542.1 | 1 | UniProt (Q13950) Pfam (PF00853) | Homo sapiens (Human) | Acute myeloid leukemia 3 protein,Core-binding factor subunit alpha-1,CBF-alpha-1,Oncogene AML-3,Osteoblast-specific transcription factor 2,OSF-2,Polyomavirus enhancer-binding protein 2 alpha A subunit,PEBP2-alpha A,SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core-binding factor alpha A subunit |
| 5 | E (G) | Core-binding factor subunit beta | polymer | 156 | 18263.4 | 1 | UniProt (Q13951) Pfam (PF02312) | Homo sapiens (Human) | CBF-beta,Polyomavirus enhancer-binding protein 2 beta subunit,PEBP2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit |
Sequence modifications
A: 276 - 375 (UniProt: Q01543)
G: 1 - 142 (UniProt: Q13951)
| PDB | External Database | Details |
|---|---|---|
| Gly 272 | - | expression tag |
| Pro 273 | - | expression tag |
| His 274 | - | expression tag |
| Met 275 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 59701.6 | |
| All* | Total formula weight | 59701.6 |
