6VGC
Crystal Structures of FLAP bound to DG-031
Summary for 6VGC
| Entry DOI | 10.2210/pdb6vgc/pdb |
| Descriptor | 5-lipoxygenase-activating protein, (2R)-cyclopentyl{4-[(quinolin-2-yl)methoxy]phenyl}acetic acid, CALCIUM ION, ... (5 entities in total) |
| Functional Keywords | 5-lipoxygenase activating protein, flap, dg-031, membrane protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 6 |
| Total formula weight | 118504.29 |
| Authors | Ho, J.D.,Lee, M.R.,Rauch, C.T.,Aznavour, K.,Park, J.S.,Luz, J.G.,Antonysamy, S.,Condon, B.,Maletic, M.,Zhang, A.,Hickey, M.J.,Hughes, N.E.,Chandrasekhar, S.,Sloan, A.V.,Gooding, K.,Harvey, A.,Yu, X.P.,Kahl, S.D.,Norman, B.H. (deposition date: 2020-01-07, release date: 2020-12-02, Last modification date: 2023-10-11) |
| Primary citation | Ho, J.D.,Lee, M.R.,Rauch, C.T.,Aznavour, K.,Park, J.S.,Luz, J.G.,Antonysamy, S.,Condon, B.,Maletic, M.,Zhang, A.,Hickey, M.J.,Hughes, N.E.,Chandrasekhar, S.,Sloan, A.V.,Gooding, K.,Harvey, A.,Yu, X.P.,Kahl, S.D.,Norman, B.H. Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP). Biochim Biophys Acta Gen Subj, 1865:129800-129800, 2020 Cited by PubMed Abstract: Due to the importance of both prostaglandins (PGs) and leukotrienes (LTs) as pro-inflammatory mediators, and the potential for eicosanoid shunting in the presence of pathway target inhibitors, we have investigated an approach to inhibiting the formation of both PGs and LTs as part of a multi-targeted drug discovery effort. PubMed: 33246032DOI: 10.1016/j.bbagen.2020.129800 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.37 Å) |
Structure validation
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