6VGC
Crystal Structures of FLAP bound to DG-031
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | 5-lipoxygenase-activating protein | polymer | 171 | 19327.2 | 6 | UniProt (P20292) Pfam (PF01124) | Homo sapiens (Human) | FLAP, MK-886-binding protein |
| 2 | G, H, J, K, M... (A, B, C, D, E...) | (2R)-cyclopentyl{4-[(quinolin-2-yl)methoxy]phenyl}acetic acid | non-polymer | 361.4 | 6 | Chemie (QY1) | |||
| 3 | I, L (B, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | O (F) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 1 | Chemie (BOG) | |||
| 5 | P, Q, R, S, T... (A, B, C, D, E...) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 2 - 161 (UniProt: P20292)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Ser 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Ala 148 | Lys 148 | conflict |
| Glu 162 | - | expression tag |
| Gly 163 | - | expression tag |
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| His 166 | - | expression tag |
| His 167 | - | expression tag |
| His 168 | - | expression tag |
| His 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 115963.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2541.1 | |
| All* | Total formula weight | 118504.3 |
