6VEO

ATAD2B bromodomain in complex with 4-({[(3R,4R)-4-{[3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl]amino}piperidin-3-yl]oxy}methyl)-1lambda~6~-thiane-1,1-dione (compound 38)

6VEO の概要

• エントリーDOI: 10.2210/pdb6veo/pdb
• 分子名称: ATPase family AAA domain-containing protein 2B, SULFATE ION, 4-({[(3R,4R)-4-{[3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl]amino}piperidin-3-yl]oxy}methyl)-1lambda~6~-thiane-1,1-dione, ... (4 entities in total)
• 機能のキーワード: bromodomain, epigenetics, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16529.85

構造登録者

Glass, K.C. (登録日: 2020-01-02, 公開日: 2020-10-28, 最終更新日: 2023-10-11)

• 主引用文献: Lloyd, J.T.,McLaughlin, K.,Lubula, M.Y.,Gay, J.C.,Dest, A.,Gao, C.,Phillips, M.,Tonelli, M.,Cornilescu, G.,Marunde, M.R.,Evans, C.M.,Boyson, S.P.,Carlson, S.,Keogh, M.C.,Markley, J.L.,Frietze, S.,Glass, K.C.; Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain.; J.Med.Chem., 63:12799-12813, 2020; PubMed: 33084328; DOI: 10.1021/acs.jmedchem.0c01178

実験手法

X-RAY DIFFRACTION (2.4 Å)