6VDB

SETD2 in complex with a H3-variant super-substrate peptide

6VDB の概要

• エントリーDOI: 10.2210/pdb6vdb/pdb
• 分子名称: Histone-lysine N-methyltransferase SETD2, ALA-PRO-ARG-PHE-GLY-GLY-VAL-MET-ARG-PRO-ASN-ARG, S-ADENOSYL-L-HOMOCYSTEINE, ... (7 entities in total)
• 機能のキーワード: transferase, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37726.69

構造登録者

Beldar, S.,Tempel, W.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Jeltsch, A.,Min, J.,Structural Genomics Consortium,Structural Genomics Consortium (SGC) (登録日: 2019-12-24, 公開日: 2020-01-29, 最終更新日: 2023-10-11)

• 主引用文献: Schuhmacher, M.K.,Beldar, S.,Khella, M.S.,Brohm, A.,Ludwig, J.,Tempel, W.,Weirich, S.,Min, J.,Jeltsch, A.; Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.; Commun Biol, 3:511-511, 2020; PubMed: 32939018; DOI: 10.1038/s42003-020-01223-6

実験手法

X-RAY DIFFRACTION (2.3 Å)