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6VBN

Crystal Structure of hTDO2 bound to inhibitor GNE1

Summary for 6VBN
Entry DOI10.2210/pdb6vbn/pdb
DescriptorTryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, 1,5-anhydro-2,3-dideoxy-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-D-threo-pentitol, ... (4 entities in total)
Functional Keywordstdo, ido, cancer immunotherapy, heme, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight185534.04
Authors
Harris, S.F.,Oh, A. (deposition date: 2019-12-19, release date: 2020-05-06, Last modification date: 2023-10-11)
Primary citationParr, B.T.,Pastor, R.,Sellers, B.D.,Pei, Z.,Jaipuri, F.A.,Castanedo, G.M.,Gazzard, L.,Kumar, S.,Li, X.,Liu, W.,Mendonca, R.,Pavana, R.K.,Potturi, H.,Shao, C.,Velvadapu, V.,Waldo, J.P.,Wu, G.,Yuen, P.W.,Zhang, Z.,Zhang, Y.,Harris, S.F.,Oh, A.J.,DiPasquale, A.,Dement, K.,La, H.,Goon, L.,Gustafson, A.,VanderPorten, E.C.,Mautino, M.R.,Liu, Y.
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
Acs Med.Chem.Lett., 11:541-549, 2020
Cited by
PubMed: 32292562
DOI: 10.1021/acsmedchemlett.0c00004
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.18 Å)
Structure validation

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