6VBN
Crystal Structure of hTDO2 bound to inhibitor GNE1
Summary for 6VBN
Entry DOI | 10.2210/pdb6vbn/pdb |
Descriptor | Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, 1,5-anhydro-2,3-dideoxy-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-D-threo-pentitol, ... (4 entities in total) |
Functional Keywords | tdo, ido, cancer immunotherapy, heme, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 185534.04 |
Authors | Harris, S.F.,Oh, A. (deposition date: 2019-12-19, release date: 2020-05-06, Last modification date: 2023-10-11) |
Primary citation | Parr, B.T.,Pastor, R.,Sellers, B.D.,Pei, Z.,Jaipuri, F.A.,Castanedo, G.M.,Gazzard, L.,Kumar, S.,Li, X.,Liu, W.,Mendonca, R.,Pavana, R.K.,Potturi, H.,Shao, C.,Velvadapu, V.,Waldo, J.P.,Wu, G.,Yuen, P.W.,Zhang, Z.,Zhang, Y.,Harris, S.F.,Oh, A.J.,DiPasquale, A.,Dement, K.,La, H.,Goon, L.,Gustafson, A.,VanderPorten, E.C.,Mautino, M.R.,Liu, Y. Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors. Acs Med.Chem.Lett., 11:541-549, 2020 Cited by PubMed: 32292562DOI: 10.1021/acsmedchemlett.0c00004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.18 Å) |
Structure validation
Download full validation report