6VBN
Crystal Structure of hTDO2 bound to inhibitor GNE1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tryptophan 2,3-dioxygenase | polymer | 385 | 45510.7 | 4 | UniProt (P48775) Pfam (PF03301) | Homo sapiens (Human) | TDO,Tryptamin 2,3-dioxygenase,Tryptophan oxygenase,TRPO,Tryptophan pyrrolase,Tryptophanase |
| 2 | E, G, I, L (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, H, J, K (A, B, C) | 1,5-anhydro-2,3-dideoxy-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-D-threo-pentitol | non-polymer | 256.3 | 4 | Chemie (QVY) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 18 - 388 (UniProt: P48775)
| PDB | External Database | Details |
|---|---|---|
| Met 15 | - | expression tag |
| Gly 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Gly 389 | - | expression tag |
| Asn 390 | - | expression tag |
| Ser 391 | - | expression tag |
| Asp 392 | - | expression tag |
| Tyr 393 | - | expression tag |
| Lys 394 | - | expression tag |
| Asp 395 | - | expression tag |
| Asp 396 | - | expression tag |
| Asp 397 | - | expression tag |
| Asp 398 | - | expression tag |
| Lys 399 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 182042.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3491.1 | |
| All* | Total formula weight | 185534.0 |
