6VBN
Crystal Structure of hTDO2 bound to inhibitor GNE1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Tryptophan 2,3-dioxygenase | polymer | 385 | 45510.7 | 4 | UniProt (P48775) Pfam (PF03301) In PDB | Homo sapiens (Human) | TDO,Tryptamin 2,3-dioxygenase,Tryptophan oxygenase,TRPO,Tryptophan pyrrolase,Tryptophanase |
2 | A, B, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
3 | A, B, C | 1,5-anhydro-2,3-dideoxy-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-D-threo-pentitol | non-polymer | 256.3 | 4 | Chemie (QVY) | |||
4 | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 18 - 388 (UniProt: P48775)
PDB | External Database | Details |
---|---|---|
Met 15 | - | expression tag |
Gly 16 | - | expression tag |
Ser 17 | - | expression tag |
Gly 389 | - | expression tag |
Asn 390 | - | expression tag |
Ser 391 | - | expression tag |
Asp 392 | - | expression tag |
Tyr 393 | - | expression tag |
Lys 394 | - | expression tag |
Asp 395 | - | expression tag |
Asp 396 | - | expression tag |
Asp 397 | - | expression tag |
Asp 398 | - | expression tag |
Lys 399 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 182042.9 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 3491.1 | |
All* | Total formula weight | 185534.0 |