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6VBN

Crystal Structure of hTDO2 bound to inhibitor GNE1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Tryptophan 2,3-dioxygenasepolymer38545510.74UniProt (P48775)
Pfam (PF03301)
Homo sapiens (Human)TDO,Tryptamin 2,3-dioxygenase,Tryptophan oxygenase,TRPO,Tryptophan pyrrolase,Tryptophanase
2E, G, I, L
(A, B, C, D)
PROTOPORPHYRIN IX CONTAINING FEnon-polymer616.54Chemie (HEM)
3F, H, J, K
(A, B, C)
1,5-anhydro-2,3-dideoxy-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-D-threo-pentitolnon-polymer256.34Chemie (QVY)
4M, N, O, P
(A, B, C, D)
waterwater18.036Chemie (HOH)
Sequence modifications
A, B, C, D: 18 - 388 (UniProt: P48775)
PDBExternal DatabaseDetails
Met 15-expression tag
Gly 16-expression tag
Ser 17-expression tag
Gly 389-expression tag
Asn 390-expression tag
Ser 391-expression tag
Asp 392-expression tag
Tyr 393-expression tag
Lys 394-expression tag
Asp 395-expression tag
Asp 396-expression tag
Asp 397-expression tag
Asp 398-expression tag
Lys 399-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight182042.9
Non-Polymers*Number of molecules8
Total formula weight3491.1
All*Total formula weight185534.0
*Water molecules are not included.

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PDB entries from 2025-08-13

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