6V8K

Crystal structure of the p300 acetyltransferase domain with peptide-competitive inhibitor 2

Summary for 6V8K

• Entry DOI: 10.2210/pdb6v8k/pdb
• Related: 6V8B
• Descriptor: Histone acetyltransferase p300, COENZYME A, 1-(2-methyl-1H-indol-3-yl)-2-[(2R)-2-methylpiperidin-1-yl]ethan-1-one, ... (5 entities in total)
• Functional Keywords: epigenetics, chromatin, writer, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 38301.52

Authors

Gardberg, A.S. (deposition date: 2019-12-11, release date: 2020-04-01, Last modification date: 2024-04-03)

• Primary citation: Huhn, A.J.,Gardberg, A.S.,Poy, F.,Brucelle, F.,Vivat, V.,Cantone, N.,Patel, G.,Patel, C.,Cummings, R.,Sims, R.,Levell, J.,Audia, J.E.,Bommi-Reddy, A.,Wilson, J.E.; Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.; Chemmedchem, 15:955-960, 2020; PubMed: 32181984; DOI: 10.1002/cmdc.202000007

Experimental method

X-RAY DIFFRACTION (1.84 Å)