6V8K
Crystal structure of the p300 acetyltransferase domain with peptide-competitive inhibitor 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Histone acetyltransferase p300 | polymer | 323 | 37185.5 | 1 | UniProt (Q09472) Pfam (PF08214) In PDB | Homo sapiens (Human) | p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein propionyltransferase p300 |
| 2 | A | COENZYME A | non-polymer | 767.5 | 1 | Chemie (COA) | |||
| 3 | A | 1-(2-methyl-1H-indol-3-yl)-2-[(2R)-2-methylpiperidin-1-yl]ethan-1-one | non-polymer | 270.4 | 1 | Chemie (QS4) | |||
| 4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A: 1287 - 1519 (UniProt: Q09472)
A: 1581 - 1663 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Gly 1285 | - | expression tag |
| Ser 1286 | - | expression tag |
| Phe 1467 | Tyr 1467 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 1576 | - | linker |
| Gly 1577 | - | linker |
| Gly 1578 | - | linker |
| Ser 1579 | - | linker |
| Gly 1580 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37185.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1116.0 | |
| All* | Total formula weight | 38301.5 |
