6V5P

EGFR(T790M/V948R) in complex with LN2725

Summary for 6V5P

Entry DOI	10.2210/pdb6v5p/pdb
Descriptor	Epidermal growth factor receptor, 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1H-imidazol-5-yl]-2-phenyl-3H-pyrrolo[2,3-b]pyridine, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	egfr, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	151729.77
Authors	Heppner, D.E.,Eck, M.J. (deposition date: 2019-12-04, release date: 2020-04-22, Last modification date: 2023-10-11)
Primary citation	Heppner, D.E.,Gunther, M.,Wittlinger, F.,Laufer, S.A.,Eck, M.J. Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J.Med.Chem., 63:4293-4305, 2020 Cited by PubMed: 32243152 DOI: 10.1021/acs.jmedchem.0c00200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation