6V5P
EGFR(T790M/V948R) in complex with LN2725
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Epidermal growth factor receptor | polymer | 328 | 37479.4 | 4 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | E, G, I, J (A, B, C, D) | 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1H-imidazol-5-yl]-2-phenyl-3H-pyrrolo[2,3-b]pyridine | non-polymer | 426.5 | 4 | Chemie (QP4) | |||
| 3 | F, H, K (A, B, D) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 374 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 149917.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1812.3 | |
| All* | Total formula weight | 151729.8 |
