6V3F

Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1)

6V3F の概要

• エントリーDOI: 10.2210/pdb6v3f/pdb
• EMDBエントリー: 21035
• 分子名称: NPC1-like intracellular cholesterol transporter 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: cholesterol, transporter, tunnel, sterol, intestine, ezetimibe, sterol-sensing domain, lipid transport
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 151936.53

構造登録者

Huang, C.S.,Yu, X.,Min, X.,Wang, Z. (登録日: 2019-11-25, 公開日: 2020-07-01, 最終更新日: 2020-07-29)

• 主引用文献: Huang, C.S.,Yu, X.,Fordstrom, P.,Choi, K.,Chung, B.C.,Roh, S.H.,Chiu, W.,Zhou, M.,Min, X.,Wang, Z.; Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition; Sci Adv, 6:eabb1989-, 2020; DOI: 10.1126/sciadv.abb1989

実験手法

ELECTRON MICROSCOPY (3.7 Å)