6V2E

Crystal structure of the human CLR:RAMP2 extracellular domain heterodimer with bound high-affinity adrenomedullin S45R/K46L/S48G/Q50W variant

6V2E の概要

• エントリーDOI: 10.2210/pdb6v2e/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 2,Calcitonin gene-related peptide type 1 receptor, ADM, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: class b gpcr, peptide hormone, membrane protein
• 由来する生物種: Escherichia coli (strain K12); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68664.85

構造登録者

Booe, J.M.,Pioszak, A.A. (登録日: 2019-11-22, 公開日: 2020-08-05, 最終更新日: 2023-10-11)

• 主引用文献: Booe, J.M.,Warner, M.L.,Pioszak, A.A.; Picomolar Affinity Antagonist and Sustained Signaling Agonist Peptide Ligands for the Adrenomedullin and Calcitonin Gene-Related Peptide Receptors.; Acs Pharmacol Transl Sci, 3:759-772, 2020; PubMed: 32832875; DOI: 10.1021/acsptsci.0c00031

実験手法

X-RAY DIFFRACTION (1.83 Å)