6V17

Crystal structure of the bromodomain of human BRD7 bound to I-BRD9

Summary for 6V17

Entry DOI	10.2210/pdb6v17/pdb
Descriptor	Bromodomain-containing protein 7, CHLORIDE ION, N'-[1,1-bis(oxidanylidene)thian-4-yl]-5-ethyl-4-oxidanylidene-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide, ... (4 entities in total)
Functional Keywords	non-bet, bromodomain, pbaf, mswi/snf, bp75, celtix1, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	29819.85
Authors	Karim, M.R.,Chan, A.,Schonbrunn, E. (deposition date: 2019-11-19, release date: 2020-03-11, Last modification date: 2023-10-11)
Primary citation	Karim, R.M.,Chan, A.,Zhu, J.Y.,Schonbrunn, E. Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J.Med.Chem., 63:3227-3237, 2020 Cited by PubMed: 32091206 DOI: 10.1021/acs.jmedchem.9b01980 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation