6UZ8

Cryo-EM structure of human TRPC6 in complex with agonist AM-0883

Summary for 6UZ8

Entry DOI	10.2210/pdb6uz8/pdb
EMDB information	20953
Descriptor	Short transient receptor potential channel 6, 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, CHOLESTEROL HEMISUCCINATE, ... (4 entities in total)
Functional Keywords	trp channel, agonist, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	396575.42
Authors	Bai, Y.,Yu, X.,Huang, X.,Chen, H. (deposition date: 2019-11-14, release date: 2020-03-18)
Primary citation	Bai, Y.,Yu, X.,Chen, H.,Horne, D.,White, R.,Wu, X.,Lee, P.,Gu, Y.,Ghimire-Rijal, S.,Lin, D.C.,Huang, X. Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9:-, 2020 Cited by PubMed: 32149605 DOI: 10.7554/eLife.53311 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.84 Å)

Structure validation