6UYC

Crystal structure of TEAD2 bound to Compound 2

6UYC の概要

• エントリーDOI: 10.2210/pdb6uyc/pdb
• 分子名称: Transcriptional enhancer factor TEF-4, N-{5-[(E)-2-(4,4-difluorocyclohexyl)ethenyl]-6-methoxypyridin-3-yl}methanesulfonamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: tead, yap binding domain, transcription inhibitor, palmitoylation inhibitor, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54221.20

構造登録者

Noland, C.L.,Holden, J.K.,Crawford, J.J.,Zbieg, J.R.,Cunningham, C.N. (登録日: 2019-11-12, 公開日: 2020-06-24, 最終更新日: 2023-10-11)

• 主引用文献: Holden, J.K.,Crawford, J.J.,Noland, C.L.,Schmidt, S.,Zbieg, J.R.,Lacap, J.A.,Zang, R.,Miller, G.M.,Zhang, Y.,Beroza, P.,Reja, R.,Lee, W.,Tom, J.Y.K.,Fong, R.,Steffek, M.,Clausen, S.,Hagenbeek, T.J.,Hu, T.,Zhou, Z.,Shen, H.C.,Cunningham, C.N.; Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.; Cell Rep, 31:107809-107809, 2020; PubMed: 32579935; DOI: 10.1016/j.celrep.2020.107809

実験手法

X-RAY DIFFRACTION (1.658 Å)