6UWQ

Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with SDDC-0001565 inhibitor

Summary for 6UWQ

• Entry DOI: 10.2210/pdb6uwq/pdb
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ... (5 entities in total)
• Functional Keywords: ssgcid, dhfr, structure-guided drug discovery coalition, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase
• Biological source: Mycobacterium ulcerans (strain Agy99)
• Total number of polymer chains: 1
• Total formula weight: 20263.57

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2019-11-05, release date: 2020-11-11, Last modification date: 2023-10-11)

• Primary citation: Mayclin, S.J.,Abendroth, J.A.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.; Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with SDDC-0001565 inhibitor; to be published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)