Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | binding site for residue NAP A 201 |
| Chain | Residue |
| A | TRP16 |
| A | ARG55 |
| A | THR56 |
| A | VAL75 |
| A | THR76 |
| A | ARG77 |
| A | GLN78 |
| A | GLY90 |
| A | ILE108 |
| A | GLY109 |
| A | GLY110 |
| A | ALA17 |
| A | ALA111 |
| A | GLN112 |
| A | ILE113 |
| A | TYR114 |
| A | LEU116 |
| A | QKJ202 |
| A | EDO203 |
| A | HOH328 |
| A | HOH338 |
| A | HOH341 |
| A | ILE24 |
| A | HOH377 |
| A | HOH382 |
| A | HOH419 |
| A | HOH449 |
| A | GLY25 |
| A | ARG26 |
| A | GLY28 |
| A | GLY29 |
| A | GLY53 |
| A | ARG54 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue QKJ A 202 |
| Chain | Residue |
| A | ILE15 |
| A | TRP16 |
| A | GLY29 |
| A | ILE30 |
| A | ASP37 |
| A | PHE41 |
| A | LEU60 |
| A | ILE108 |
| A | TYR114 |
| A | NAP201 |
| A | HOH420 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 203 |
| Chain | Residue |
| A | ARG26 |
| A | ASP27 |
| A | GLY28 |
| A | ARG55 |
| A | GLU138 |
| A | NAP201 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 204 |
| Chain | Residue |
| A | TRP32 |
| A | ARG33 |
| A | LEU34 |
| A | HOH304 |
| A | HOH334 |
| A | HOH456 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrdggIPWrlpe.DlahFkrlT |
| Chain | Residue | Details |
| A | VAL23-THR45 | |
