6US8
Influenza A M2 proton channel wild type TM domain bound to S-rimantadine
Summary for 6US8
Entry DOI | 10.2210/pdb6us8/pdb |
Descriptor | Matrix protein 2, CHLORIDE ION, (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, ... (4 entities in total) |
Functional Keywords | proton channel, rimantadine, membrane protein |
Biological source | Influenza A virus (A/Jinfang/132/2002(H3N2)) |
Total number of polymer chains | 16 |
Total formula weight | 46362.88 |
Authors | Thomaston, J.L.,DeGrado, W.F. (deposition date: 2019-10-25, release date: 2020-10-28, Last modification date: 2023-10-11) |
Primary citation | Thomaston, J.L.,Samways, M.L.,Konstantinidi, A.,Ma, C.,Hu, Y.,Bruce Macdonald, H.E.,Wang, J.,Essex, J.W.,DeGrado, W.F.,Kolocouris, A. Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity. Biochemistry, 2021 Cited by PubMed: 34342217DOI: 10.1021/acs.biochem.1c00437 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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