6UON
Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation
Summary for 6UON
Entry DOI | 10.2210/pdb6uon/pdb |
Descriptor | TCR-V-alpha-12-02*01, TCR-V-beta-10-2*01, HLA class I antigen, ... (5 entities in total) |
Functional Keywords | hla-c neoantigen kras, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 10 |
Total formula weight | 188492.86 |
Authors | Sun, P.D.,Sim, M.J.W. (deposition date: 2019-10-15, release date: 2020-05-27, Last modification date: 2023-10-11) |
Primary citation | Sim, M.J.W.,Lu, J.,Spencer, M.,Hopkins, F.,Tran, E.,Rosenberg, S.A.,Long, E.O.,Sun, P.D. High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D. Proc.Natl.Acad.Sci.USA, 117:12826-12835, 2020 Cited by PubMed: 32461371DOI: 10.1073/pnas.1921964117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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