6UON
Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (G, I) | TCR-V-alpha-12-02*01 | polymer | 202 | 22471.9 | 2 | Homo sapiens (Human) | ||
| 2 | B, D (H, J) | TCR-V-beta-10-2*01 | polymer | 241 | 27314.3 | 2 | Homo sapiens (Human) | ||
| 3 | E, H (A, D) | HLA class I antigen | polymer | 274 | 31837.1 | 2 | UniProt (C1K0Y1) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (Human) | MHC class I antigen,MHC class I histocompatibility antigen |
| 4 | F, I (B, E) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 2 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 5 | G, J (C, F) | GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA-LEU | polymer | 10 | 875.0 | 2 | UniProt (P01111) | Homo sapiens |
Sequence modifications
C, F: 1 - 10 (UniProt: P01111)
| PDB | External Database | Details |
|---|---|---|
| Asp 3 | Gly 12 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 188492.9 | |
| All* | Total formula weight | 188492.9 |
