6UM8

HIV Integrase in complex with Compound-14

Summary for 6UM8

Entry DOI	10.2210/pdb6um8/pdb
Descriptor	Integrase, PENTAETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	dna integration, aids, rnaseh, ledgf, endonuclease, hiv-1 integrase, transferase, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	38992.06
Authors	Khan, J.A.,Kish, K. (deposition date: 2019-10-09, release date: 2020-03-04, Last modification date: 2023-10-11)
Primary citation	Li, G.,Meanwell, N.A.,Krystal, M.R.,Langley, D.R.,Naidu, B.N.,Sivaprakasam, P.,Lewis, H.,Kish, K.,Khan, J.A.,Ng, A.,Trainor, G.L.,Cianci, C.,Dicker, I.B.,Walker, M.A.,Lin, Z.,Protack, T.,Discotto, L.,Jenkins, S.,Gerritz, S.W.,Pendri, A. Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors. J.Med.Chem., 63:2620-2637, 2020 Cited by PubMed: 32081010 DOI: 10.1021/acs.jmedchem.9b01681 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation